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生长抑素及生长抑素类似物SMS 201-995对三种人乳腺癌细胞系的抗增殖作用。

Antiproliferative effects of somatostatin and the somatostatin analog SMS 201-995 on three human breast cancer cell lines.

作者信息

Scambia G, Panici P B, Baiocchi G, Perrone L, Iacobelli S, Mancuso S

机构信息

Istituto di Clinica Ginecologia e Ostetrica, Università Cattolica, Roma, Italy.

出版信息

J Cancer Res Clin Oncol. 1988;114(3):306-8. doi: 10.1007/BF00405839.

DOI:10.1007/BF00405839
PMID:2898476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12243764/
Abstract

The antiproliferative effect of somatostatin and the somatostatin analog SMS 201-995 on three human breast cancer cell lines (CG5, T 47 D, and ZR 75-1) is reported. Both peptides markedly inhibited CG5 cell growth with a maximal inhibition of about 40% as compared with control cells. The antiproliferative effect of somatostatin on T 47 D and ZR 75-1 cells was much less evident. These results suggest that somatostatin is a peptide inhibitory factor for human breast cancer cells. Possible therapeutic implications of these findings are still to be investigated.

摘要

据报道，生长抑素和生长抑素类似物SMS 201-995对三种人乳腺癌细胞系（CG5、T 47 D和ZR 75-1）具有抗增殖作用。与对照细胞相比，两种肽均显著抑制CG5细胞生长，最大抑制率约为40%。生长抑素对T 47 D和ZR 75-1细胞的抗增殖作用则不太明显。这些结果表明，生长抑素是一种对人乳腺癌细胞具有抑制作用的肽类因子。这些发现的潜在治疗意义仍有待研究。