Spring-Mills E J, Stearns S B, Numann P J, Smith P H
Life Sci. 1984 Jul 9;35(2):185-90. doi: 10.1016/0024-3205(84)90138-3.
Four types of human breast lesions and C3H mouse mammary adenocarcinomas (type A) were examined for the immunocytochemical localization of cells containing hormone-like substances. Insulin- or somatostatin-like immunoreactive material was observed in scattered single cells and nests of tumor cells in seven of eight infiltrating duct carcinomas, and in the majority of tumor cells from an anaplastic carcinoma. A few somatostatin-immunoreactive cells were observed in only one of seven fibroadenomas studied. No immunoreactive cells were observed in mouse adenocarcinomas or in human breast dysplasias. These results suggest that cells with hormone-like immunoreactivity may be a common feature in two types of malignant human breast tumors.
对四种人类乳腺病变和C3H小鼠乳腺腺癌（A型）进行了检测，以确定含激素样物质细胞的免疫细胞化学定位。在8例浸润性导管癌中的7例以及1例间变性癌的大多数肿瘤细胞中，在散在的单个细胞和肿瘤细胞巢中观察到胰岛素样或生长抑素样免疫反应性物质。在所研究的7例纤维腺瘤中，仅在其中1例中观察到少数生长抑素免疫反应性细胞。在小鼠腺癌或人类乳腺发育异常中未观察到免疫反应性细胞。这些结果表明，具有激素样免疫反应性的细胞可能是两种人类恶性乳腺肿瘤的共同特征。
