ω-3 脂肪酸在胆固醇逆转运中的作用：综述。
The Role of Omega-3 Fatty Acids in Reverse Cholesterol Transport: A Review.
机构信息
Department of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, 6020 Innsbruck, Austria.
出版信息
Nutrients. 2017 Oct 6;9(10):1099. doi: 10.3390/nu9101099.
The beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on cardiovascular disease have been studied extensively. However, it remains unclear to what extent n-3 PUFAs may impact Reverse Cholesterol Transport (RCT). RCT describes a mechanism by which excess cholesterol from peripheral tissues is transported to the liver for hepatobiliary excretion, thereby inhibiting foam cell formation and the development of atherosclerosis. The aim of this review is to summarize the literature and to provide an updated overview of the effects of n-3 PUFAs on key players in RCT, including apoliprotein AI (apoA-I), ATP-binding cassette transporter A1 (ABCA1), ABCG1, apoE, scavenger receptor class B type I (SR-BI), cholesteryl ester transfer protein (CETP), low-density lipoprotein receptor (LDLr), cholesterol 7 alpha-hydroxylase (CYP7A1) and ABCG5/G8. Based on current knowledge, we conclude that n-3 PUFAs may beneficially affect RCT, mainly by influencing high-density lipoprotein (HDL) remodeling and by promoting hepatobiliary sterol excretion.
ω-3 多不饱和脂肪酸（n-3PUFAs）对心血管疾病的有益影响已经得到了广泛的研究。然而，n-3PUFAs 对胆固醇逆向转运（RCT）的影响程度仍不清楚。RCT 描述了一种机制，即外周组织多余的胆固醇被运送到肝脏进行肝胆排泄，从而抑制泡沫细胞的形成和动脉粥样硬化的发展。本综述的目的是总结文献，并提供 n-3PUFAs 对 RCT 关键参与者的影响的最新概述，包括载脂蛋白 AI（apoA-I）、三磷酸腺苷结合盒转运蛋白 A1（ABCA1）、ABCG1、载脂蛋白 E（apoE）、清道夫受体 B 类 I（SR-BI）、胆固醇酯转移蛋白（CETP）、低密度脂蛋白受体（LDLr）、胆固醇 7α-羟化酶（CYP7A1）和 ABCG5/G8。基于目前的知识，我们得出结论，n-3PUFAs 可能通过影响高密度脂蛋白（HDL）重塑和促进肝胆固醇排泄，对 RCT 产生有益影响。
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