妊娠期疟疾：动物模型在疫苗研发中的相关性
Malaria in pregnancy: the relevance of animal models for vaccine development.
作者信息
Doritchamou Justin, Teo Andrew, Fried Michal, Duffy Patrick E
机构信息
Laboratory of Malaria Immunology &Vaccinology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, Maryland, USA.
出版信息
Lab Anim (NY). 2017 Oct 6;46(10):388-398. doi: 10.1038/laban.1349.
Abstract
Malaria during pregnancy due to Plasmodium falciparum or P. vivax is a major public health problem in endemic areas, with P. falciparum causing the greatest burden of disease. Increasing resistance of parasites and mosquitoes to existing tools, such as preventive antimalarial treatments and insecticide-treated bed nets respectively, is eroding the partial protection that they offer to pregnant women. Thus, development of effective vaccines against malaria during pregnancy is an urgent priority. Relevant animal models that recapitulate key features of the pathophysiology and immunology of malaria in pregnant women could be used to accelerate vaccine development. This review summarizes available rodent and nonhuman primate models of malaria in pregnancy, and discusses their suitability for studies of biologics intended to prevent or treat malaria in this vulnerable population.
摘要
由恶性疟原虫或间日疟原虫引起的妊娠疟疾是流行地区的一个主要公共卫生问题，其中恶性疟原虫造成的疾病负担最大。寄生虫和蚊子对现有工具（如预防性抗疟治疗和经杀虫剂处理的蚊帐）的耐药性不断增加，正在削弱它们为孕妇提供的部分保护。因此，开发针对妊娠疟疾的有效疫苗是当务之急。可利用能够概括孕妇疟疾病理生理学和免疫学关键特征的相关动物模型来加速疫苗开发。本综述总结了现有的妊娠疟疾啮齿动物和非人类灵长类动物模型，并讨论了它们在研究旨在预防或治疗这一脆弱人群疟疾的生物制品方面的适用性。
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