通过三组分多米诺反应微波辅助区域选择性合成3-官能化吲哚衍生物
Microwave-Assisted Regioselective Synthesis of 3-Functionalized Indole Derivatives via Three-Component Domino Reaction.
作者信息
Lin Wei, Zheng Yong-Xiang, Xun Zhan, Huang Zhi-Bin, Shi Da-Qing
机构信息
College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, P. R. China.
School of Chemistry and Environmental Engineering, Jiangsu University of Technology , Changzhou 213001, P. R. China.
出版信息
ACS Comb Sci. 2017 Nov 13;19(11):708-713. doi: 10.1021/acscombsci.7b00126. Epub 2017 Oct 18.
A microwave-assisted regioselective synthesis of 3-functionalized indole derivatives via a three-component domino reaction of anilines, arylglyoxal monohydrates, and cyclic 1,3-dicarbonyl compounds is described. The main advantages of this protocol are short reaction times, practical simplicity, its metal-free nature, the availability of starting materials, green solvents, and high regioselectivity.
描述了一种通过苯胺、芳基乙二醛一水合物和环状1,3 - 二羰基化合物的三组分多米诺反应微波辅助区域选择性合成3 - 官能化吲哚衍生物的方法。该方法的主要优点是反应时间短、操作简便、无金属性质、起始原料易得、使用绿色溶剂以及区域选择性高。
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