Nanotechnology. 2017 Dec 8;28(49):495601. doi: 10.1088/1361-6528/aa91c4.
Facile synthesis of core-shell magnetic MOFs for drug delivery is of significance due to the advantages of high drug load and easy separation. In this work, magnetic metal organic frameworks (MOFs, FeO-NH@MIL101-NH) core-shell nanoparticles were synthesized rapidly in water phase by microwave irradiation using Fe and 2-amino-1,4-benzenedicarboxylate (BDC-NH) as metal ions and ligands respectively. The resulting magnetic MOFs exhibit large surface areas (96.04 m g), excellent magnetic response (20.47 emu g) and large mesopore volume (22.07 cm g) along with spherical morphologies with the diameters ranging from 140-330 nm. Using doxorubicin (DOX) as a model drug, the drug loading capacity of FeO-NH@MIL101-NH could reach 36.02%, substantially higher than pristine MIL101-NH. Importantly, the release of DOX could be controlled by pH as well as the meso pore size of MOFs. The cytotoxicity assay showed that the magnetic MOFs have low cytotoxicity and good biocompatibility. The results suggest great potential of the magnetic MOFs core-shell nanoparticles fabricated in this study on controlled drug release of DOX.
由于高载药量和易于分离的优点，用于药物输送的核壳型磁性金属有机骨架（MOFs）的简便合成具有重要意义。在这项工作中，使用 Fe 和 2-氨基-1,4-苯二甲酸（BDC-NH）分别作为金属离子和配体，通过微波辐射在水相中快速合成了磁性 MOFs（FeO-NH@MIL101-NH）核壳纳米粒子。所得磁性 MOFs 具有大的比表面积（96.04 m g）、优异的磁响应（20.47 emu g）和大的中孔体积（22.07 cm g）以及 140-330 nm 范围内的球形形貌。以阿霉素（DOX）为模型药物，FeO-NH@MIL101-NH 的载药能力可达 36.02%，远高于原始 MIL101-NH。重要的是，DOX 的释放可以通过 pH 值以及 MOFs 的中孔尺寸来控制。细胞毒性试验表明，磁性 MOFs 具有低细胞毒性和良好的生物相容性。研究结果表明，所制备的磁性 MOFs 核壳纳米粒子在 DOX 的控制释放方面具有很大的潜力。
