Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria; Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, United Kingdom; Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu Campus, Nigeria.
Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.
Fitoterapia. 2019 Apr;134:151-157. doi: 10.1016/j.fitote.2019.02.019. Epub 2019 Feb 27.
Bioassay-guided fractionation of the leaves of Macaranga barteri collected from Nigeria led to the isolation of three previously undescribed cytotoxic stilbenes, macabartebenes A-C (1-3), together with six known compounds including prenylated stilbenes: vedelianin (4), schweinfurthin G (5), and mappain (7), prenylated flavonols: 8-prenylkaempferol (6), and broussoflavonol F (8), and the geranylated flavonol, isomacarangin (9). The cytotoxicity of the compounds was evaluated against four human cancer cell lines, with vinblastine as the positive control and DMSO vehicle as the negative control. Vedelianin (IC = 0.32-0.54 μM) displayed the greatest antiproliferative activity across the panel of cancer cell lines amongst the compounds, while macabartebene A (IC = 0.60-0.79 μM) was the most potent of the previously unreported compounds. The compounds displayed varying selectivity towards the cancer cell lines compared to the normal human prostate cell line. The findings of this study revealed that M. barteri leaves contain several cytotoxic compounds.
从尼日利亚采集的大琴叶榕叶经生物测定指导分离，得到了三种以前未描述的细胞毒性二苯乙烯，即 macabartebenes A-C（1-3），以及六种已知化合物，包括：prenylated stilbenes：vedelianin（4）、schweinfurthin G（5）和 mappain（7）；prenylated flavonols：8-prenylkaempferol（6）和 broussoflavonol F（8）；以及 geranylated flavonol，isomacarangin（9）。评估了这些化合物对四种人癌细胞系的细胞毒性，以长春碱作为阳性对照，DMSO 溶剂作为阴性对照。在该组化合物中，vedelianin（IC 50 = 0.32-0.54 μM）对各种癌细胞系显示出最强的抗增殖活性，而 macabartebene A（IC 50 = 0.60-0.79 μM）是以前未报道的化合物中最有效的。与正常人前列腺细胞系相比，这些化合物对癌细胞系表现出不同的选择性。本研究结果表明，大琴叶榕叶含有几种细胞毒性化合物。
