Rao K V, Puri V N
Department of Medicinal Chemistry, College of Pharmacy, J. Hillis Miller Health Center, University of Florida, Gainesville 32610.
Life Sci. 1988;42(26):2717-20. doi: 10.1016/0024-3205(88)90248-2.
Manassantin A (MNS-A), a novel neolignoid, neutral compound shown to possess neuroleptic properties, causes hypothermic response in male and female mice of CD-1 strain when administered by the intra-cerebroventricular (icv), (0.1, 1.0, 3.2, 10 micrograms/mouse), intraperitoneal (ip), (0.1, 0.32, 1.0, 3.2 mg/kg) and oral (0.5, 1.6, 5.0, 16 mg/kg) routes. The hypothermia was found to be dose and time dependent, the maximum decrease of temperature being observed by the icv route (P less than 0.001) after 2 hours. However, ip and oral administration of lower and middle order doses were not very effective but higher doses caused significant (P less than 0.001) reduction of body temperature. The centrally-induced hypothermic response by MNS-A may give future leads as a screening model for antidepressant drugs and can be a useful tool for manipulating physiological and pharmacological processes to understand the central thermoregulatory functions.
马纳桑亭A（MNS - A）是一种新型的新木脂素类中性化合物，已显示具有抗精神病特性。当通过脑室内（icv，剂量为0.1、1.0、3.2、10微克/小鼠）、腹腔内（ip，剂量为0.1、0.32、1.0、3.2毫克/千克）和口服（剂量为0.5、1.6、5.0、16毫克/千克）途径给药时，会使CD - 1品系的雄性和雌性小鼠产生体温过低反应。发现体温过低呈剂量和时间依赖性，2小时后通过脑室内途径观察到温度下降幅度最大（P < 0.001）。然而，腹腔内和口服较低和中等剂量时效果不太明显，但较高剂量会导致体温显著下降（P < 0.001）。MNS - A引起的中枢性体温过低反应可能为未来作为抗抑郁药物筛选模型提供线索，并且可能成为操纵生理和药理过程以了解中枢体温调节功能的有用工具。
