Liliedahl R L, Ryan C F, Piepho R W
J Pharm Sci. 1975 May;64(5):835-8. doi: 10.1002/jps.2600640524.
Intraperitoneal administration of allylglycine resulted in a hypothermic response in rats. At a dosage of 90 mg/kg, a significant decrease in temperature was noted at 4 and 8 hr after administration, but no significant difference was noted at 12 hr. The same dose administered intraperitoneally to decapitated rats did not result in a hypothermic response, and intraventricular administration resulted in a rapid onset of hypothermia after 1 hr. These findings are indicative of a central site of action for the allylglycine-induced hypothermia. Quantitative assay of hypothalamic monoamines (norepinephrine, serotonin, and dopamine) did not show any significant changes at 4, 8, and 12 hr postadministration when compared to controls. A significant decrease in hypothalamic gamma-aminobutyric acid was noted at each of these time points when compared to controls. These data suggest an important role for gamma-aminobutyric acid in mammalian thermoregulatory control.
给大鼠腹腔注射烯丙基甘氨酸会引起体温降低反应。剂量为90毫克/千克时，给药后4小时和8小时体温显著下降，但12小时时未观察到显著差异。对断头大鼠腹腔注射相同剂量未引起体温降低反应，而脑室内注射1小时后体温迅速降低。这些发现表明烯丙基甘氨酸诱导体温降低的作用部位在中枢。与对照组相比，给药后4小时、8小时和12小时下丘脑单胺类物质（去甲肾上腺素、血清素和多巴胺）的定量测定未显示任何显著变化。与对照组相比，在这些时间点的每一个下丘脑γ-氨基丁酸均显著减少。这些数据表明γ-氨基丁酸在哺乳动物体温调节控制中起重要作用。
