Stump B S, Bane A J, Avery D D
Department of Psychology, Colorado State University, Fort Collins 80523.
Pharmacol Biochem Behav. 1994 Aug;48(4):881-5. doi: 10.1016/0091-3057(94)90195-3.
Bombesin (BBS), a tetradecapeptide, has been found to have potent hypothermic effects when centrally administered. This study was designed to investigate the relationship between food-deprivation and BBS-induced hypothermia in a temperature selection paradigm. Food-deprived and satiated male Sprague-Dawley rats were given intracerebroventricular (ICV) injections of several doses of BBS and control vehicle. Selection temperature data and changes in core body temperature were measured. BBS produced a significant hypothermia and decrease in selection temperatures in all doses but one. No significant differences in body temperature or selection temperatures were found between food-deprived and satiated animals. The results are consistent with the hypothesis that BBS acts centrally to decrease body temperature set point.
蛙皮素（BBS）是一种十四肽，研究发现当进行中枢给药时，它具有强大的降温作用。本研究旨在通过温度选择范式，探究饥饿与BBS诱导的体温过低之间的关系。对饥饿和饱腹的雄性斯普拉格-道利大鼠进行脑室内（ICV）注射几种剂量的BBS和对照赋形剂。测量选择温度数据和核心体温变化。除一个剂量外，BBS在所有剂量下均产生显著的体温过低和选择温度降低。饥饿和饱腹动物之间在体温或选择温度上未发现显著差异。结果与BBS通过中枢作用降低体温调定点的假设一致。
