Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
Eur J Med Chem. 2017 Nov 10;140:331-348. doi: 10.1016/j.ejmech.2017.09.020. Epub 2017 Sep 14.
The role of natural products in the drug development and discovery has been phenomenal. There has been an enormous interest in exploring all possible natural sources to identify structures exhibiting pronounced hypolipidemic activity albeit with no toxicity. The present review describes the profile of some interesting naturally occurring compounds and their derivatives as potential hypolipidemic agents. Some of the interesting natural chemotypes that can control the increased levels of plasma lipids and discussed in this review are compactin, lovastatin, gugglesterone, berberine, lupeol, phytol, polyprenol, aegeline, 4-hydroxyisoleucine, α-asarone, resveratrol, esculeoside A, swertiamarin, rutin, saucerneol B, curcumin and a clerodane diterpene.
天然产物在药物开发和发现中的作用是惊人的。人们对探索所有可能的天然来源产生了浓厚的兴趣，以确定具有显著降血脂活性且无毒的结构。本综述描述了一些具有潜在降血脂作用的有趣天然化合物及其衍生物的概况。本文综述了一些可以控制血浆脂质水平升高的有趣天然化学型，如考来烯胺、洛伐他汀、gugglesterone、小檗碱、羽扇豆醇、植醇、多聚异戊烯、aegeline、4-羟基异亮氨酸、α-细辛脑、白藜芦醇、 Esculeoside A、苦玄参苷 I、芦丁、香叶醇 B、姜黄素和 clerodane 二萜。
