Retina Division, Department of Ophthalmology, L.V. Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India.
Department of Ophthalmology and Visual Sciences, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Surv Ophthalmol. 2018 May-Jun;63(3):307-328. doi: 10.1016/j.survophthal.2017.09.008. Epub 2017 Oct 5.
Because of complications and side effects, conventional laser therapy has taken a back seat to drugs in the treatment of macular diseases. Despite this, research on new laser modalities remains active. In particular, various approaches are being pursued to preserve and improve retinal structure and function. These include micropulsing, various exposure titration algorithms, and real-time temperature feedback control of short-pulse continuous wave lasers, and ultra-short-pulse nanosecond lasers. Some of these approaches are at the preclinical stage of development, whereas others are available for clinical use. Cell biology is providing important insights into the mechanisms of action of retinal laser treatment. We outline the technological bases of current laser platforms, their basic science, therapeutic concepts, clinical experience, and future directions for retinal laser treatment.
由于并发症和副作用，传统的激光疗法在治疗黄斑疾病方面已退居二线，让位于药物。尽管如此，新的激光模式的研究仍然活跃。特别是，正在寻求各种方法来保护和改善视网膜的结构和功能。这些方法包括微脉冲、各种曝光滴定算法以及短脉冲连续波激光和超短脉冲纳秒激光的实时温度反馈控制。其中一些方法处于临床前开发阶段，而另一些则可用于临床应用。细胞生物学为视网膜激光治疗的作用机制提供了重要的见解。我们概述了当前激光平台的技术基础、它们的基础科学、治疗概念、临床经验以及视网膜激光治疗的未来方向。
