State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing 211166, China.
Suzhou Affiliated Hospital of Nanjing Medical University, 26 Daoqian Road, Suzhou 215002, JiangSu Province, China.
Sci Total Environ. 2018 Feb 15;615:369-374. doi: 10.1016/j.scitotenv.2017.09.236. Epub 2017 Oct 4.
Recent studies have identified that exposure to particulate matter during pregnancy could result in adverse birth outcomes, but the effects of exposure at trimester-specific intervals are inconsistent.
Our primary goal was to investigate whether particulate matter exposure during pregnancy could affect birth weight and gestational age of neonates.
A retrospective cohort study was conducted to examine the relationship between maternal particulate matter exposure and neonatal birth weight. We collected 14,455 births records linked to hospital admission records (delivery and antenatal) from January 2013 to December 2015 in Suzhou Municipal Hospital. Air monitoring data in the same timeframe were also collected from Suzhou Environmental Protection Agency. The risk of low birth weight due to the exposure to PM (with median aerodynamic diameter≤2.5μm) and PM (with median aerodynamic diameter≤10μm) at each trimester and throughout the entire pregnancy were assessed. Linear regression models were applied and potential confounding factors were adjusted for data analysis. Gestational age, which was another important birth outcome, and its association with maternal particulate matter exposure were also studied.
The final analysis included 10,915 singleton live births. Using multiple linear regression models, we found that gestational exposure to PM and PM at 10μg/m increments in the second trimester led to decreases in birth weight of 4.94g (95% confidence interval: -9.828, -0.046) and 5.65g (95% confidence interval: -10.110, -1.188), respectively. However, gestational age was not significantly associated with maternal particulate matter exposure in term neonates.
These findings indicate that pregnant women might be more susceptible to particulate matter during the second trimester which may lead to decreased neonatal birth weight.
最近的研究表明，孕期暴露于颗粒物可能会导致不良的出生结局，但暴露于特定孕期时间间隔的影响并不一致。
我们的主要目标是研究孕期颗粒物暴露是否会影响新生儿的出生体重和胎龄。
我们进行了一项回顾性队列研究，以检验孕妇颗粒物暴露与新生儿出生体重之间的关系。我们收集了 2013 年 1 月至 2015 年 12 月苏州市立医院的 14455 份分娩记录，这些记录与住院记录（分娩和产前）相关联。同时，我们还从苏州市环境保护局收集了同一时期的空气质量监测数据。评估了孕期暴露于 PM（中值空气动力学直径≤2.5μm）和 PM（中值空气动力学直径≤10μm）在每个孕期和整个孕期对低出生体重的风险。应用线性回归模型，并对数据进行了潜在混杂因素的调整。胎龄是另一个重要的出生结局，我们也研究了它与孕妇颗粒物暴露之间的关系。
最终分析包括 10915 例单胎活产儿。使用多元线性回归模型，我们发现，孕中期 PM 和 PM 暴露量每增加 10μg/m，出生体重分别下降 4.94g（95%置信区间：-9.828，-0.046）和 5.65g（95%置信区间：-10.110，-1.188）。然而，胎龄与足月新生儿的母亲颗粒物暴露无显著相关性。
这些发现表明，孕妇在孕中期可能更容易受到颗粒物的影响，这可能导致新生儿出生体重下降。
