Cheng Hiu Yee Heidi, Kan Anita Sik-Yau, Hui Pui Wah, Lee Chin Peng, Tang Mary Hoi Yin
Department of Obstetrics and Gynaecology, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong.
Arch Gynecol Obstet. 2017 Dec;296(6):1109-1116. doi: 10.1007/s00404-017-4534-2. Epub 2017 Oct 7.
The use of array comparative genomic hybridization (aCGH) has been increasingly widespread. The challenge of integration of this technology into prenatal diagnosis was the interpretation of results and communicating findings of unclear clinical significance. This study assesses the knowledge and acceptance of prenatal aCGH in Hong Kong obstetricians and pregnant women. The aim is to identify the needs and gaps before implementing the replacement of karyotyping with aCGH. Questionnaires with aCGH information in the form of pamphlets were sent by post to obstetrics and gynecology doctors.
For the pregnant women group, a video presentation, pamphlets on aCGH and a self-administered questionnaire were provided at the antenatal clinic.
The perception of aCGH between doctors and pregnant women was similar. Doctors not choosing aCGH were more concerned about the difficulty in counseling of variants of unknown significance and adult-onset disease in pregnant women, whereas pregnant women not choosing aCGH were more concerned about the increased waiting time leading to increased anxiety. Prenatal aCGH is perceived as a better test by both doctors and patients.
Counseling support, training, and better understanding and communication of findings of unclear clinical significance are necessary to improve doctor-patient experience.
阵列比较基因组杂交（aCGH）的应用日益广泛。将该技术整合到产前诊断中的挑战在于结果的解读以及传达临床意义不明确的检查结果。本研究评估了香港产科医生和孕妇对产前aCGH的了解程度和接受情况。目的是在实施用aCGH取代核型分析之前，确定需求和差距。以小册子形式包含aCGH信息的问卷通过邮寄方式发送给妇产科医生。
对于孕妇组，在产前诊所提供了视频演示、关于aCGH的小册子以及一份自填式问卷。
医生和孕妇对aCGH的看法相似。不选择aCGH的医生更担心在为孕妇咨询意义不明的变异和成人发病疾病方面存在困难，而不选择aCGH的孕妇更担心等待时间延长会导致焦虑增加。医生和患者都认为产前aCGH是一种更好的检测方法。
为改善医患体验，提供咨询支持、培训以及更好地理解和沟通临床意义不明确的检查结果是必要的。
