Bejko Jonida, Toto Francesca, Gregori Dario, Gerosa Gino, Bottio Tomaso
Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Medical School, Padova, Italy.
J Artif Organs. 2018 Mar;21(1):52-60. doi: 10.1007/s10047-017-0997-y. Epub 2017 Oct 7.
Different left ventricular assist devices (LVADs) are provided of different driveline exit sites: HeartWare HVAD presents abdominal power-cable-supply, while the Jarvik 2000 LVAD is powered by a retroauricular driveline. We analyzed 93 LVAD-implanted patients from January-2009 to October-2016 (41 HeartWare and 52 Jarvik 2000), hypothesizing a different incidence of infection, according to driveline exit site. The two populations were propensity matched for the demographic data and preoperative variables, and the outcomes were further analyzed. Nine driveline infections (DLIs) were in each LVAD group recorded (22% for HVAD and 17% for Jarvik 2000). The incidence of the complication was similar between groups (p = 0.97), even during time (p = 0.27 within 6 months and p = 0.16 over 6 months of support). Age at implant (p = 0.01), revision for bleeding (p = 0.05), days of postoperative intubation (p = 0.002), and ICU stay (p < 0.001), as well as days on device (p < 0.001) were identified as risk factors for DLIs. The type of device and the driveline exit site were not statistically co-related to infections. Similar infection-freedom survival was identified (p = 0.87). Younger age at implant, revision for bleeding, prolonged mechanical ventilation, delayed rehabilitation, as well as long time LVAD support were identified as risk factors for exit site DLIs. Despite similar incidence of DLIs, the different management and care of the retroauricular exit site makes it more appropriate and comfortable in long-term support.
不同的左心室辅助装置(LVAD)具有不同的驱动线出口部位:HeartWare HVAD的动力电缆供应位于腹部,而Jarvik 2000 LVAD由耳后驱动线供电。我们分析了2009年1月至2016年10月期间93例植入LVAD的患者(41例HeartWare和52例Jarvik 2000),根据驱动线出口部位假设感染发生率不同。对这两组人群的人口统计学数据和术前变量进行倾向匹配,并进一步分析结果。每个LVAD组均记录了9例驱动线感染(DLIs)(HeartWare HVAD为22%,Jarvik 2000为17%)。两组之间并发症的发生率相似(p = 0.97),即使在不同时间段也是如此(支持6个月内p = 0.27,支持6个月以上p = 0.16)。植入时的年龄(p = 0.01)、因出血进行的翻修(p = 0.05)、术后插管天数(p = 0.002)、重症监护病房停留时间(p < 0.001)以及使用装置的天数(p < 0.001)被确定为DLIs的危险因素。装置类型和驱动线出口部位与感染在统计学上无相关性。两组的无感染生存率相似(p = 0.87)。植入时年龄较小、因出血进行翻修、机械通气时间延长、康复延迟以及LVAD长期支持被确定为出口部位DLIs的危险因素。尽管DLIs的发生率相似,但耳后出口部位不同的管理和护理使其在长期支持中更合适、更舒适。