鼻窦上皮在变应性鼻炎中的作用。
The Role of the Sinonasal Epithelium in Allergic Rhinitis.
作者信息
London Nyall R, Ramanathan Murugappan
机构信息
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins, Baltimore, MD, USA.
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins, Baltimore, MD, USA.
出版信息
Otolaryngol Clin North Am. 2017 Dec;50(6):1043-1050. doi: 10.1016/j.otc.2017.08.002. Epub 2017 Oct 6.
Abstract
The sinonasal epithelial barrier is comprised of tight and adherens junction proteins. Disruption of epithelial barrier function has been hypothesized to contribute to allergic disease such as allergic rhinitis through increased passage of antigens and exposure of underlying tissue to these stimuli. Several mechanisms of sinonasal epithelial barrier disruption include antigen proteolytic activity, inflammatory cytokine-mediated tight junction breakdown, or exacerbation from environmental stimuli. Mechanisms of sinonasal epithelial barrier stabilization include corticosteroids and nuclear erythroid 2-related factor 2 (Nrf2) cytoprotective pathway activation. Additional studies will aid in determining the contribution of epithelial barrier function in allergic rhinitis pathophysiology and treatment.
摘要
鼻窦上皮屏障由紧密连接蛋白和黏附连接蛋白组成。上皮屏障功能的破坏被认为会通过增加抗原的通过以及使下层组织暴露于这些刺激而导致过敏性疾病，如过敏性鼻炎。鼻窦上皮屏障破坏的几种机制包括抗原蛋白水解活性、炎症细胞因子介导的紧密连接破坏或环境刺激的加剧。鼻窦上皮屏障稳定的机制包括皮质类固醇和核红细胞2相关因子2（Nrf2）细胞保护途径的激活。更多的研究将有助于确定上皮屏障功能在过敏性鼻炎病理生理学和治疗中的作用。
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