Nur Husna Siti Muhamad, Md Shukri Norasnieda, Tan Hern-Tze Tina, Mohd Ashari Noor Suryani, Wong Kah Keng
Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
Department of Otorhinolaryngology, Head and Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
Front Med (Lausanne). 2022 Feb 28;9:843432. doi: 10.3389/fmed.2022.843432. eCollection 2022.
Allergic rhinitis (AR) is a global health burden and it manifests in both nasal and non-nasal symptoms. Skin prick test (SPT) is a routine procedure to diagnose AR sensitized to common allergens including house dust mites (HDMs). The degree of sensitivity of a patient toward allergens is determined by the size of the wheal formed by SPT procedure. SPT wheal sizes are influenced by recent anti-histamine usage, however it remains unclear if SPT wheal sizes are also influenced by other factors. In this study, we set out to investigate the association between SPT wheal sizes with the demographical, clinical and environmental characteristics, as well as nasal and non-nasal symptoms severity scores, of AR patients ( = 30) sensitized to common HDMs (i.e., , and ). We showed that SPT wheal sizes of HDM allergens were not associated with clinical, demographical and environmental characteristics examined. Nonetheless, significant correlations were observed between SPT wheal sizes of sensitization with worse severity scores of all five nasal symptoms examined (i.e., sneezing, runny nose, itchy nose, congestion and postnasal drip) and four of the six non-nasal symptoms examined (i.e., throat symptoms, ear symptoms, headache and mental function). Such relationships were not observed in SPT wheal sizes of and sensitization. We suggest that increased SPT wheal sizes for sensitization may predict the likelihood of more severe nasal and, to a lesser extent, non-nasal manifestations in AR patients.
变应性鼻炎（AR）是一种全球性的健康负担，它表现为鼻部和非鼻部症状。皮肤点刺试验（SPT）是诊断对包括屋尘螨（HDM）在内的常见变应原致敏的AR的常规检查。患者对变应原的敏感程度由SPT检查所形成的风团大小决定。SPT风团大小受近期抗组胺药使用情况的影响，然而SPT风团大小是否也受其他因素影响仍不清楚。在本研究中，我们着手调查对常见HDM（即，和）致敏的AR患者（ = 30）的SPT风团大小与人口统计学、临床和环境特征以及鼻部和非鼻部症状严重程度评分之间的关联。我们发现，HDM变应原的SPT风团大小与所检查的临床、人口统计学和环境特征无关。尽管如此，致敏的SPT风团大小与所检查的所有五种鼻部症状（即打喷嚏、流鼻涕、鼻痒、鼻塞和鼻后滴漏）以及所检查的六种非鼻部症状中的四种（即咽喉症状、耳部症状、头痛和精神功能）的更严重严重程度评分之间存在显著相关性。在致敏和致敏的SPT风团大小中未观察到这种关系。我们认为，致敏的SPT风团大小增加可能预示AR患者出现更严重鼻部症状以及程度较轻的非鼻部表现的可能性。
