Soliman Sameh, Alnajdy Dina, El-Keblawy Ali A, Mosa Kareem A, Khoder Ghalia, Noreddin Ayman M
Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.
Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Pharmacogn Rev. 2017 Jul-Dec;11(22):104-122. doi: 10.4103/phrev.phrev_8_17.
is a serious life-threatening pathogen, particularly with immunocompromised patients. infections are considered as a major cause of morbidity and mortality in a broad range of immunocompromised patients. infections are common in hospitalized patients and elderly people. The difficulty to eradicate infections is owing to its unique switch between yeast and hyphae forms and more likely to biofilm formations that render resistance to antifungal therapy. Plants are known sources of natural medicines. Several plants show significant anti- activities and some of them have lower minimum inhibitory concentration, making them promising candidates for anti- therapy. However, none of these plant products is marketed for anti- therapy because of lack of sufficient information about their efficacy, toxicity, and kinetics. This review revises major plants that have been tested for anti- activities with recommendations for further use of some of these plants for more investigation and testing including the use of nanostructure lipid system.
是一种严重威胁生命的病原体，尤其是对于免疫功能低下的患者。感染被认为是广泛免疫功能低下患者发病和死亡的主要原因。感染在住院患者和老年人中很常见。根除感染的困难在于其在酵母和菌丝形式之间独特的转换，并且更有可能形成生物膜，从而对抗真菌治疗产生耐药性。植物是天然药物的已知来源。几种植物显示出显著的抗活性，其中一些具有较低的最低抑菌浓度，使其成为抗治疗的有希望的候选者。然而，由于缺乏关于它们的功效、毒性和动力学的充分信息，这些植物产品都没有用于抗治疗的市场销售。本综述修订了已测试抗活性的主要植物，并建议进一步使用其中一些植物进行更多研究和测试，包括使用纳米结构脂质系统。
