Shala Awad, Singh Shweta, Hameed Saif, Khurana S M Paul
Medicinal and Aromatic Plants Research Department, Horticulture Research Institute, Agricultural Research Center, Giza 12619,Egypt.
Amity Institute of Biotechnology, Amity University Haryana, Manesar, Gurugram (Manesar)-122413,India.
Curr Pharm Des. 2022;28(1):58-70. doi: 10.2174/1381612827666210914124344.
Candida albicans is one of the main agents responsible for opportunistic pathogenic infections. The progressive emergence of fungal resistance to conventional antibiotics and its side effects, as well as treatment costs, are considered major limitations for antifungal drugs. It has drawn scientists' attention to the search for potential substitution and reliable therapeutic alternatives for the antifungal compounds from sources like medicinal plants, which contain numerous bioactive compounds such as essential oils. Essential oils (EO), apart from having lower toxicity and better biodegradability, are eco-friendly in nature as compared with conventional antibiotics. Furthermore, extracted essential oils have been reported to possess potent antimicrobial, antiinflammatory, and antioxidant properties that nominate them as promising natural candidates to combat numerous fungal ailments. Thus, the determination of antifungal efficacy of essential oil-bearing plants on Candida spp. will provide miscellaneous knowledge for future clinical studies that are required for the development of new formulations as alternative therapeutic agents to control the growth of Candida species. Therefore, this review summarizes the gist of major essential oils that have been investigated for their anti- Candida potential with some recommendations for further study.
白色念珠菌是引起机会性致病感染的主要病原体之一。真菌对传统抗生素的耐药性不断出现及其副作用，以及治疗成本，被认为是抗真菌药物的主要局限性。这促使科学家们关注从药用植物等来源寻找抗真菌化合物的潜在替代品和可靠的治疗选择，药用植物含有许多生物活性化合物，如精油。与传统抗生素相比，精油不仅毒性较低、生物降解性较好，而且本质上对环境友好。此外，据报道，提取的精油具有强大的抗菌、抗炎和抗氧化特性，使其成为对抗多种真菌疾病的有前途的天然候选物。因此，测定含精油植物对念珠菌属的抗真菌效果，将为未来临床研究提供多方面的知识，这些研究是开发新制剂作为替代治疗剂以控制念珠菌生长所必需的。因此，本综述总结了已研究其抗念珠菌潜力的主要精油的要点，并提出了一些进一步研究的建议。
