Jalani Krishnendu, Dhiman Shikha, Jain Ankit, George Subi J
Supramolecular Chemistry Laboratory , New Chemistry Unit , Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) , Jakkur , Bangalore , India-560064 . Email:
Chem Sci. 2017 Aug 1;8(9):6030-6036. doi: 10.1039/c7sc01730h. Epub 2017 Jul 11.
The spatial and temporal control of self-assemblies is the latest scientific hurdle in supramolecular chemistry which is inspired by the functioning of biological systems fueled by chemical signals. In this study, we work towards alleviating this scenario by employing a unique amphiphilic foldamer that operates under the effect of a chemical fuel. The conformational changes in the foldamer amplify into observable morphological changes in its amphiphilic assembly that are controlled by external molecular cues (fuel). We take advantage of this redox responsive foldamer to affect its conformation in a temporal manner by an enzymatic pathway. The temporal characteristics of the transient conformation/assembly can be modulated by varying the concentrations of the fuel and enzyme. We believe that such a design strategy can have positive consequences in designing molecular and supramolecular systems for future active, adaptive and autonomous materials.
自组装的时空控制是超分子化学领域最新的科学难题，它受到由化学信号驱动的生物系统功能的启发。在本研究中，我们致力于通过使用一种独特的两亲性折叠体来缓解这种情况，该折叠体在化学燃料的作用下发挥作用。折叠体中的构象变化放大为其两亲性组装体中可观察到的形态变化，这些变化由外部分子线索（燃料）控制。我们利用这种氧化还原响应性折叠体，通过酶促途径以时间依赖性方式影响其构象。瞬态构象/组装体的时间特征可以通过改变燃料和酶的浓度来调节。我们相信，这样的设计策略在设计未来用于活性、适应性和自主性材料的分子和超分子系统方面会产生积极的影响。
