Dhiman Shikha, Sarkar Aritra, George Subi J
Supramolecular Chemistry Laboratory, New Chemistry Unit, School of Advanced Materials (SAMat), Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Jakkur Bangalore India-560064 http://www.jncasr.ac.in/george
RSC Adv. 2018 May 22;8(34):18913-18925. doi: 10.1039/c8ra03225d.
Thriving natural systems precisely regulate their complex chemical organizations in space and time by recruitment of a complex network of fuel-driven, kinetically controlled, out-of-equilibrium transformations. Indeed this provides an active, adaptive and autonomous smart actions & functions. In contrast, synthetic systems exhibit simpler behavior owing to thermodynamically driven supramolecular polymerization with no temporal modulation of spatial organization. Stimulated by an outstanding control that nature demonstrates, a drive towards artificial out-of-equilibrium systems with the ambition to program activation and duration of structural transformations has emerged. To realize this vision, overwhelming efforts across the globe have been initiated to design temporally programmed synthetic supramolecular polymers. In an attempt to contribute to this trending field, our supramolecular chemistry group has thoroughly investigated a structure-property relationship that determines the mechanism of supramolecular polymerization. Exploiting these mechanistic insights, along with a bio-inspired fuel-driven enzyme mediated approach, we further attempted to program supramolecular polymers in both structural and temporal regimes. We believe, nature is the inspiration to the current era challenges and it also provides with the solution, a fuel-driven approach to address these. In this account, we shall discuss the efforts made by our group to build generic concept to create temporally programmable supramolecular polymers.
蓬勃发展的自然系统通过招募一个由燃料驱动、动力学控制、非平衡转变组成的复杂网络，在空间和时间上精确调节其复杂的化学组成。事实上，这提供了主动、自适应和自主的智能行为与功能。相比之下，合成系统由于热力学驱动的超分子聚合而表现出更简单的行为，且空间组织没有时间调制。受自然界所展示的卓越控制的启发，人们已经开始努力构建具有编程激活和结构转变持续时间能力的人工非平衡系统。为了实现这一愿景，全球范围内已经展开了巨大努力来设计具有时间程序的合成超分子聚合物。为了对这一热门领域做出贡献，我们的超分子化学团队深入研究了决定超分子聚合机制的结构-性质关系。利用这些机理见解，结合受生物启发的燃料驱动酶介导方法，我们进一步尝试在结构和时间方面对超分子聚合物进行编程。我们相信，自然是当今时代挑战的灵感来源，同时也提供了解决方案，即一种燃料驱动的方法来应对这些挑战。在本报告中，我们将讨论我们团队为建立通用概念以创建具有时间可编程性的超分子聚合物所做的努力。
