Supramolecular Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bangalore, 560064, India.
Angew Chem Int Ed Engl. 2017 Jan 24;56(5):1329-1333. doi: 10.1002/anie.201610946. Epub 2016 Dec 29.
Synthetic manifestations of supramolecular chirality have extensively drawn inspiration from naturally occurring systems. Even though in biological systems conformational changes are dissipative, synthetic systems that change conformation under non-equilibrium conditions have still not been established. Herein, we attempt to alleviate this scenario by reporting a synthetic supramolecular system that undergoes temporal changes in its helical conformation as an active system at the expense of a biologically relevant chemical fuel, ATP. Use of enzymes working in tandem provides transient and switchable helices with modular lifetime and stereomutation rates.
超分子手性的合成表现从天然系统中广泛汲取了灵感。尽管在生物系统中构象变化是耗散的，但尚未建立在非平衡条件下改变构象的合成系统。在此，我们试图通过报告一个合成超分子系统来缓解这种情况，该系统作为一个主动系统，以生物学相关的化学燃料 ATP 为代价，经历其螺旋构象的时间变化。串联使用的酶提供了具有模块化寿命和立体异构化速率的瞬态和可切换螺旋。
