用于肿瘤成像的高量子产率染料的研发。

Development of a high quantum yield dye for tumour imaging.

作者信息

Yang Dan, Wang Huasen, Sun Chengjie, Zhao Hui, Hu Kuan, Qin Weirong, Ma Rui, Yin Feng, Qin Xuan, Zhang Qianling, Liang Yongye, Li Zigang

机构信息

School of Chemical Biology and Biotechnology , Shenzhen Graduate School of Peking University , Shenzhen , 518055 , China . Email:

Department of Materials Science and Engineering , South University of Science and Technology of China , Shenzhen 518055 , China . Email:

出版信息

Chem Sci. 2017 Sep 1;8(9):6322-6326. doi: 10.1039/c7sc02698f. Epub 2017 Jul 19.

A fluorescent dye, FEB, with high fluorescence quantum yield for tumour imaging is reported. FEB dyes can be efficiently synthesized in three steps and then easily modified with either PEG or PEG-iRGD to yield FEB-2000 or FEB-2000-iRGD, respectively. Both modified dyes showed negligible toxicity and were thus able to be adopted for tumour imaging. PEG modification endowed the dye FEB-2000 with both long circulating times and good tumour targeting properties in a MDA-MB-231 xenograft model. Further conjugation with iRGD to generate FEB-2000-iRGD showed minimal targeting enhancement. These results provide a template for the efficient preparation of FEB dyes for use in tumour imaging, thus providing a foundation for future modifications.