Bajaj Sarita, Kashyap Richi, Srivastava Anubha, Singh Smriti
Department of Medicine, Motilal Nehru Medical College, Allahabad, Uttar Pradesh, India.
Indian J Endocrinol Metab. 2017 Sep-Oct;21(5):695-698. doi: 10.4103/ijem.IJEM_146_17.
This study aims to assess glycemic and lipid derangement in acute and chronic liver disorders.
A cross-sectional study was conducted on 104 patients diagnosed with acute or chronic liver disorder. Acute liver disease (ALD) patients were 40 and chronic liver disease (CLD) patients were 64.
The mean value of fasting plasma glucose (FPG) in patients with ALD was 91.8 ± 5.4 mg/dl and in CLD was 115.7 ± 17.9 mg/dl, the difference was significant. The mean value of A1c was 4.3 ± 0.6 in ALD and 6.1 ± 0.8 in CLD, the difference was significant. In patients with CLD mean cholesterol was higher 177.4 ± 28.8 mg/dl when compared to ALD 140 ± 35.1 mg/dl, but the difference was not significant. ALD patients' high-density lipoprotein (HDL) was 50.4 ± 5.1 mg/dl, and in CLD patients, HDL was 44.4 ± 6.1 mg/dl. In CLD mean triglyceride (T) was 148.9 ± 6.4 mg/dl while in ALD T was 134.8 ± 14.2 mg/dl, the difference was significant.
CLD is associated with glycemic derangement demonstrated by deranged FPG and A1c. In patients of ALD, no metabolic derangement was observed.
本研究旨在评估急慢性肝脏疾病中的血糖和血脂紊乱情况。
对104例诊断为急慢性肝脏疾病的患者进行了一项横断面研究。急性肝病（ALD）患者40例，慢性肝病（CLD）患者64例。
ALD患者空腹血糖（FPG）平均值为91.8±5.4mg/dl，CLD患者为115.7±17.9mg/dl，差异有统计学意义。ALD患者糖化血红蛋白（A1c）平均值为4.3±0.6，CLD患者为6.1±0.8，差异有统计学意义。CLD患者平均胆固醇水平高于ALD患者，分别为177.4±28.8mg/dl和140±35.1mg/dl，但差异无统计学意义。ALD患者高密度脂蛋白（HDL）为50.4±5.1mg/dl，CLD患者为44.4±6.1mg/dl。CLD患者平均甘油三酯（T）为148.9±6.4mg/dl，ALD患者为134.8±14.2mg/dl，差异有统计学意义。
CLD与FPG和A1c紊乱所显示的血糖紊乱有关。在ALD患者中，未观察到代谢紊乱。
