β受体阻滞剂对原发性高血压患者淋巴细胞增殖反应的作用
Beta-blocker action on lymphocyte proliferative response in essential hypertension.
作者信息
Krasnikova T L, Kozlova M V, Kalentchuk V U, Parfenova E V, Radiukhin V A, Shkhvatsabaya I K
机构信息
USSR Cardiology Research Centre of the Academy of Medical Sciences of the USSR, Moscow.
出版信息
Cor Vasa. 1988;30(2):110-4.
The proliferative response of phytohaemagglutinin (PHA) - stimulated lymphocytes of healthy donors and hypertensive subjects was analysed according to 3H-thymidine incorporation and cell cycle phase position on a flow cytofluorimeter. 3H-thymidine uptake and the percentage of cells in (S + G2) phase were significantly lower in hypertensive patients. After short-term propranolol administration the lymphocyte blastogenic response in essential hypertension increased by 30--100%. The data suggest that the change in mitogenic response of lymphocytes in essential hypertension results from changes in the distribution of lymphocyte subclasses. The connection between the sympathoadrenal and immune system is discussed.
根据3H-胸腺嘧啶核苷掺入量以及流式细胞荧光计检测的细胞周期阶段位置，分析了健康供体和高血压患者受植物血凝素（PHA）刺激的淋巴细胞的增殖反应。高血压患者的3H-胸腺嘧啶核苷摄取量以及处于（S + G2）期的细胞百分比显著降低。短期给予普萘洛尔后，原发性高血压患者的淋巴细胞增殖反应增加了30%至100%。数据表明，原发性高血压患者淋巴细胞有丝分裂反应的变化是由淋巴细胞亚群分布的改变引起的。文中还讨论了交感肾上腺系统与免疫系统之间的联系。
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