1 Department of Internal Medicine and Medical Specialties, Sapienza University of Rome , Rome, Italy .
2 Department of Experimental Medicine, Sapienza University of Rome , Rome, Italy .
Antioxid Redox Signal. 2018 Jun 10;28(17):1576-1581. doi: 10.1089/ars.2017.7296. Epub 2017 Nov 10.
Habitual physical activity has beneficial effects on cardiovascular risk reduction by improving vascular function but the underlying mechanism is still unclear. To address this issue, we performed a cross-sectional study comparing 50 physically active (PA) adults with 50 sedentary controls matched for age, sex, and cardiovascular risk factors. PA subjects had significantly higher flow-mediated dilation (FMD) than controls and higher serum levels of nitrite/nitrate, a marker of nitric oxide generation. In addition, PA subjects showed lower levels of urinary isoprostanes, a marker of reactive oxygen species (ROS) production, and lower serum levels of sNox2-dp, a validated assay to measure Nox2 activity, one of the most important enzymes producing ROS in the blood cells. FMD was independently correlated with sNox2-dp, after adjusting for possible confounding factors. Our observation leads to the hypothesis that, in adults, regular exercise preserves artery dilation through Nox2 decreased activity. Antioxid. Redox Signal. 28, 1576-1581.
习惯性的身体活动通过改善血管功能对降低心血管风险有有益影响，但潜在机制尚不清楚。为了解决这个问题，我们进行了一项横断面研究，比较了 50 名体力活动（PA）成年人和 50 名年龄、性别和心血管危险因素相匹配的久坐不动的对照组。PA 组的血流介导的扩张（FMD）明显高于对照组，且血清中亚硝酸盐/硝酸盐水平升高，这是一氧化氮生成的标志物。此外，PA 组的尿液中异前列烷水平较低，异前列烷是活性氧（ROS）产生的标志物，而血清中 sNox2-dp 水平较低，sNox2-dp 是一种经过验证的测量 Nox2 活性的检测方法，Nox2 是血细胞中产生 ROS 的最重要的酶之一。在调整了可能的混杂因素后，FMD 与 sNox2-dp 独立相关。我们的观察结果导致了这样的假设，即成年人定期运动通过降低 Nox2 活性来保持动脉扩张。抗氧化。氧化还原信号。28,1576-1581.
