Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Department of Pediatrics, Sapienza University of Rome, Rome, Italy.
Thorax. 2018 Oct;73(10):986-988. doi: 10.1136/thoraxjnl-2017-211293. Epub 2018 Feb 15.
This study explored oxidative stress, nicotinamide adenine dinucleotide phosphate oxidase-2 (Nox2) activity and endothelial function in children exposed or not to passive smoking. Compared with controls (n=57), Nox2 activity and isoprostanes were higher in children exposed to passive smoking (n=57); conversely, nitric oxide (NO) bioavailability and flow-mediated dilation were lower in children exposed to passive smoking. A bivariate analysis showed that Nox2 activity correlated with flow-mediated dilation, NO bioavailability and isoprostanes. A multivariate analysis showed that Nox2 activity was significantly associated with serum isoprostanes and cotinine levels; flow-mediated dilation was associated with isoprostanes and carotid intima-media thickness.In children exposed to passive smoking, Nox2-derived oxidative stress is upregulated and inversely associated with impaired artery dilation.
本研究旨在探讨处于被动吸烟环境与非被动吸烟环境中的儿童的氧化应激、烟酰胺腺嘌呤二核苷酸磷酸氧化酶-2（Nox2）活性和内皮功能。与对照组（n=57）相比，处于被动吸烟环境中的儿童的 Nox2 活性和异前列腺素更高（n=57）；相反，处于被动吸烟环境中的儿童的一氧化氮（NO）生物利用度和血流介导的扩张较低。双变量分析显示，Nox2 活性与血流介导的扩张、NO 生物利用度和异前列腺素呈负相关。多变量分析显示，Nox2 活性与血清异前列腺素和可替宁水平显著相关；血流介导的扩张与异前列腺素和颈动脉内膜中层厚度相关。在处于被动吸烟环境的儿童中，Nox2 衍生的氧化应激被上调，并与动脉扩张受损呈负相关。
