黄病毒非结构蛋白介导的固有免疫逃避。
Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins.
机构信息
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu 611130, China.
出版信息
Viruses. 2017 Oct 7;9(10):291. doi: 10.3390/v9100291.
Flaviviridae-caused diseases are a critical, emerging public health problem worldwide. Flaviviridae infections usually cause severe, acute or chronic diseases, such as liver damage and liver cancer resulting from a hepatitis C virus (HCV) infection and high fever and shock caused by yellow fever. Many researchers worldwide are investigating the mechanisms by which Flaviviridae cause severe diseases. Flaviviridae can interfere with the host's innate immunity to achieve their purpose of proliferation. For instance, dengue virus (DENV) NS2A, NS2B3, NS4A, NS4B and NS5; HCV NS2, NS3, NS3/4A, NS4B and NS5A; and West Nile virus (WNV) NS1 and NS4B proteins are involved in immune evasion. This review discusses the interplay between viral non-structural Flaviviridae proteins and relevant host proteins, which leads to the suppression of the host's innate antiviral immunity.
黄病毒科引起的疾病是全球一个严重的新出现的公共卫生问题。黄病毒科感染通常会导致严重、急性或慢性疾病，如丙型肝炎病毒（HCV）感染导致的肝损伤和肝癌，以及黄热病引起的高热和休克。全世界许多研究人员都在研究黄病毒科引起严重疾病的机制。黄病毒科可以干扰宿主的先天免疫以达到增殖的目的。例如，登革热病毒（DENV）的 NS2A、NS2B3、NS4A、NS4B 和 NS5；丙型肝炎病毒（HCV）的 NS2、NS3、NS3/4A、NS4B 和 NS5A；以及西尼罗河病毒（WNV）的 NS1 和 NS4B 蛋白都参与了免疫逃避。本文综述了病毒非结构黄病毒科蛋白与相关宿主蛋白之间的相互作用，导致宿主先天抗病毒免疫的抑制。
Zotero 插件