Lowry Kathryn P, Lee Susanna I
University of Washington School of Medicine, Seattle Cancer Care Alliance, 825 Eastlake Avenue East, G2-600, Seattle, WA 98109, USA.
Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, WAC 240, Boston, MA 02114, USA.
Radiol Clin North Am. 2017 Nov;55(6):1251-1259. doi: 10.1016/j.rcl.2017.06.010.
Ovarian cancer has a high mortality, attributed to its typically advanced stage at detection. Despite much effort to identify an effective approach for ovarian cancer screening, to date no screening test has proven to reduce ovarian cancer mortality. The natural history of ovarian cancer is reviewed as well as data from the largest trials of ovarian cancer screening. Currently, no North American society recommends routine ovarian cancer screening; some societies recommend consideration of screening with pelvic ultrasound and CA-125 in women at high risk, although its use in this setting is not supported by data demonstrating a mortality benefit.
卵巢癌死亡率很高，这归因于其在被发现时通常已处于晚期。尽管人们付出了很多努力来寻找一种有效的卵巢癌筛查方法，但迄今为止，尚无筛查测试被证明能降低卵巢癌死亡率。本文回顾了卵巢癌自然史以及来自最大规模卵巢癌筛查试验的数据。目前，北美没有一个学会推荐进行常规卵巢癌筛查；一些学会建议对高危女性考虑采用盆腔超声和CA-125进行筛查，不过在这种情况下使用该方法并未得到有死亡率获益数据的支持。
