Rao Harsha L, Pradhan Zia S, Weinreb Robert N, Dasari Srilakshmi, Riyazuddin Mohammed, Venugopal Jayasree P, Puttaiah Narendra K, Rao Dhanaraj A S, Devi Sathi, Mansouri Kaweh, Webers Carroll A B
*Narayana Nethralaya, Rajajinagar†Narayana Nethralaya, Hulimavu, Bangalore, Karnataka, India‡Department of Ophthalmology, Shiley Eye Institute and Hamilton Glaucoma Center, University of California, San Diego, CA§Glaucoma Center, Montchoisi Clinic, Swiss Vision Network, Lausanne, Switzerland∥Department of Ophthalmology, University of Colorado, Denver, CO¶University Eye Clinic Maastricht, University Medical Center, Maastricht, The Netherlands.
J Glaucoma. 2017 Oct;26(10):888-895. doi: 10.1097/IJG.0000000000000758.
To compare the vessel density measurements of optic nerve head, peripapillary and macular regions in severity-matched primary open-angle glaucoma (POAG) eyes with and without disc hemorrhage (DH) using optical coherence tomography (OCT) angiography, and to compare their diagnostic abilities with that of the rim area, retinal nerve fiber layer and the ganglion cell complex thickness measurements on OCT.
In a cross-sectional study, 66 eyes of 46 control subjects, 34 eyes of 33 POAG patients with DH (median mean deviation=-3.7 dB) and 63 eyes of 43 POAG patients without DH (median mean deviation=-3.8 dB) underwent imaging with spectral domain OCT. Area under receiver operating characteristic curves (AUC) and 5sensitivities at 90% specificity of vessel density and structural measurements in POAG eyes with DH were compared with those in POAG eyes without DH.
Most of the vessel density and structural measurements were similar (P>0.05) in POAG eyes with and without DH. Whole enface vessel density of the disc scan and inferotemporal peripapillary vessel density showed the best AUC and sensitivity at 90% specificity both in POAG eyes with DH (0.82, 56% and 0.75, 59%) and without DH (0.91, 73% and 0.83, 67%). AUCs and sensitivities of vessel density and structural measurements of POAG eyes with and without DH were statistically similar (P>0.05).
OCT angiography measured vessel densities and their diagnostic abilities in POAG eyes with and without DH were similar. This suggests that the cause of DH in POAG is unlikely to be vascular abnormality.
使用光学相干断层扫描血管造影术（OCTA）比较有无视盘出血（DH）的严重程度匹配的原发性开角型青光眼（POAG）患眼视神经乳头、视乳头周围和黄斑区的血管密度测量值，并将它们与OCT上的视盘面积、视网膜神经纤维层和神经节细胞复合体厚度测量值的诊断能力进行比较。
在一项横断面研究中，46名对照受试者的66只眼、33例有DH的POAG患者的34只眼（平均偏差中位数=-3.7dB）和43例无DH的POAG患者的63只眼（平均偏差中位数=-3.8dB）接受了光谱域OCT成像。比较有DH的POAG患眼中血管密度和结构测量值的受试者操作特征曲线下面积（AUC）以及90%特异性时的敏感度与无DH的POAG患眼中的相应指标。
有DH和无DH的POAG患眼中，大多数血管密度和结构测量值相似（P>0.05）。视盘扫描的全表面血管密度和颞下视乳头周围血管密度在有DH的POAG患眼中（0.82，56%和0.75，59%）以及无DH的POAG患眼中（0.91，73%和0.83，67%）均显示出90%特异性时最佳的AUC和敏感度。有DH和无DH的POAG患眼中血管密度和结构测量值的AUC和敏感度在统计学上相似（P>0.05）。
OCTA测量的有DH和无DH的POAG患眼中的血管密度及其诊断能力相似。这表明POAG中DH的原因不太可能是血管异常。
