实测（和估算）肾小球滤过率：西非参考值。
Measured (and estimated) glomerular filtration rate: reference values in West Africa.
机构信息
Département de Biochimie, UFR sciences pharmaceutiques et Biologiques, University Felix Houphouet Boigny, Abidjan, Côte D'Ivoire.
Département d'Hématologie, UFR sciences pharmaceutiques et Biologiques, University Felix Houphouet Boigny, Abidjan, Côte D'Ivoire.
出版信息
Nephrol Dial Transplant. 2018 Jul 1;33(7):1176-1180. doi: 10.1093/ndt/gfx244.
BACKGROUND
Establishment of normal reference values for glomerular filtration rate (GFR) is mandatory in nephrology. However, no data are available for measured GFR (mGFR) in Africa.
METHODS
GFR was measured in 237 healthy adult subjects (103 women and 134 men, mean age 34 ± 10 years) by iohexol plasma clearance.
RESULTS
The mean mGFR was 103 ± 17 mL/min/1.73 m2 and the median value was 103 mL/min/1.73 m2 (2.5th and 97.5th percentiles are 76 and 137 mL/min/1.73 m2, respectively). No significant difference in mGFR results was observed in patients < 40 years of age, whereas a significant decline in mGFR was observed after 40 years of age. There was no significant difference between mGFR in men and women.
CONCLUSIONS
Normal GFR values and descriptions of percentiles are now available for West Africa. As in Caucasians, no significant difference was observed between men and women. Moreover, the same age-associated decline in mGFR is also observed after 40 years of age, as in Caucasians.
背景
在肾脏病学中，建立肾小球滤过率（GFR）的正常参考值是强制性的。然而，非洲尚无可测量 GFR（mGFR）的数据。
方法
通过碘海醇血浆清除率测量了 237 名健康成年受试者（103 名女性和 134 名男性，平均年龄 34±10 岁）的 GFR。
结果
mGFR 的平均值为 103±17 mL/min/1.73 m2，中位数为 103 mL/min/1.73 m2（2.5 百分位数和 97.5 百分位数分别为 76 和 137 mL/min/1.73 m2）。<40 岁的患者 mGFR 结果无显著差异，而 40 岁后 mGFR 显著下降。男性和女性的 mGFR 无显著差异。
结论
现在可以为西非提供正常的 GFR 值和百分位数描述。与白种人一样，男性和女性之间没有观察到显著差异。此外，40 岁后，mGFR 也像白种人一样出现与年龄相关的下降。
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