Allanore Yannick, Distler Oliver, Walker Ulrich A, Khanna Dinesh, Furst Daniel E, Meune Christophe
Department of Rheumatology A, Cochin Hospital and Cochin Institute, AP-HP, Paris-Descartes University, Paris, France.
Department of Rheumatology, University Hospital Zurich, Zurich.
Rheumatology (Oxford). 2017 Sep 1;56(suppl_5):v12-v16. doi: 10.1093/rheumatology/kex198.
Cardiac involvement contributes to the severity of SSc and should carefully be investigated and managed in SSc patients. Although it is commonly sub-clinical, once symptomatic it has a poor prognosis. Several complementary tools (circulating biomarkers, electrocardiography, echocardiography, scintigraphy or MRI) allow the assessment of all the various cardiac structures (endocardium, myocardium and pericardium) and heart function. Treatment remains empirical but cardiac trials in SSc can add data to the treatment of this complication.
心脏受累会加重系统性硬化症(SSc)的病情严重程度,因此应对SSc患者进行仔细的检查和管理。虽然心脏受累通常为亚临床状态,但一旦出现症状,预后较差。多种辅助检查手段(循环生物标志物、心电图、超声心动图、闪烁扫描或磁共振成像)可用于评估心脏的各个结构(心内膜、心肌和心包)及心脏功能。目前治疗仍基于经验,但针对SSc的心脏相关试验可为该并发症的治疗增添数据。