State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; These authors contributed equally to this work.
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; These authors contributed equally to this work.
Trends Mol Med. 2017 Nov;23(11):1014-1023. doi: 10.1016/j.molmed.2017.09.004. Epub 2017 Oct 6.
Prior to zygotic genome activation, early mammalian development relies on maternal-effect genes to orchestrate the oocyte-to-embryo transition. Recently, a subcortical maternal complex (SCMC) was identified to be essential for mouse preimplantation development. The SCMC integrates multiple proteins encoded by maternal-effect genes and appears to be functionally conserved across mammalian species. In addition, mutations in human SCMC genes are associated with certain human reproductive disorders. Here, we highlight recent advances in the biology of the SCMC and propose that this complex may be a representative example of maternal functional modules in mammalian oocyte-to-embryo transition. These findings may provide further insights into the molecular regulation of mammalian early embryogenesis, with possible implications for human early embryonic development and reproduction medicine.
在合子基因组激活之前，早期哺乳动物发育依赖于母体效应基因来协调卵母细胞到胚胎的转变。最近，一个皮质下母体复合物（SCMC）被确定对小鼠着床前发育至关重要。SCMC 整合了多个母体效应基因编码的蛋白质，并且在哺乳动物物种中似乎具有功能保守性。此外，人类 SCMC 基因的突变与某些人类生殖障碍有关。在这里，我们强调了 SCMC 生物学的最新进展，并提出该复合物可能是哺乳动物卵母细胞到胚胎转变中母体功能模块的代表性例子。这些发现可能为哺乳动物早期胚胎发生的分子调控提供进一步的见解，并可能对人类早期胚胎发育和生殖医学产生影响。
