Dong Jianbao, Zhu Wei, Yamashita Nanako, Chambers James K, Uchida Kazuyuki, Kuwano Atsutoshi, Haga Takeshi
Shandong Vocational Animal Science and Veterinary College, 88, Shenglidong Street, Weifang 261061, China.
Division of Infection Control and Disease Prevention, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan.
J Vet Med Sci. 2017 Dec 6;79(12):1957-1959. doi: 10.1292/jvms.17-0322. Epub 2017 Oct 8.
Although many studies have been conducted worldwide for Equus caballus papillomavirus (EcPV), limited information is available on the virus in Japan. We recently collected one classical viral papillomatosis sample (E150904) from a racing horse in Japan. Papillomavirus infection was confirmed by histopathology, immunohistochemistry and PCR assays, and the sample was diagnosed as epithelial papilloma. Full-length genome of the virus was cloned and sequenced. It was 7,613 bp in length and had the same genome organization with reported EcPV-1. Moreover, phylogenetic analysis based on L1 gene revealed that the infection was caused by a variant of EcPV-1. This is the first report of EcPV infection in Japan, and would further contribute to the molecular epidemiological and pathological studies for EcPV.
尽管世界各地针对马乳头瘤病毒（EcPV）开展了许多研究，但关于该病毒在日本的信息却很有限。我们最近从日本一匹赛马身上采集了一份经典病毒性乳头瘤病样本（E150904）。通过组织病理学、免疫组织化学和PCR检测确认了乳头瘤病毒感染，该样本被诊断为上皮乳头瘤。对该病毒的全长基因组进行了克隆和测序。其长度为7613 bp，基因组结构与已报道的EcPV-1相同。此外，基于L1基因的系统发育分析表明，此次感染是由EcPV-1的一个变体引起的。这是日本关于EcPV感染的首次报告，将进一步推动EcPV的分子流行病学和病理学研究。
