接种牛冠状病毒疫苗的马匹对马冠状病毒的抗体反应。
Antibody response to equine coronavirus in horses inoculated with a bovine coronavirus vaccine.
作者信息
Nemoto Manabu, Kanno Toru, Bannai Hiroshi, Tsujimura Koji, Yamanaka Takashi, Kokado Hiroshi
机构信息
Equine Research Institute, Japan Racing Association, 1400-4 Shiba, Shimotsuke, Tochigi 329-0412, Japan.
Hokkaido Research Station, National Institute of Animal Health, 4 Hitsujigaoka, Toyohira, Sapporo, Hokkaido 062-0045, Japan.
出版信息
J Vet Med Sci. 2017 Nov 17;79(11):1889-1891. doi: 10.1292/jvms.17-0414. Epub 2017 Oct 6.
Abstract
A vaccine for equine coronavirus (ECoV) is so far unavailable. Bovine coronavirus (BCoV) is antigenically related to ECoV; it is therefore possible that BCoV vaccine will induce antibodies against ECoV in horses. This study investigated antibody response to ECoV in horses inoculated with BCoV vaccine. Virus neutralization tests showed that antibody titers against ECoV increased in all six horses tested at 14 days post inoculation, although the antibody titers were lower against ECoV than against BCoV. This study showed that BCoV vaccine provides horses with antibodies against ECoV to some extent. It is unclear whether antibodies provided by BCoV vaccine are effective against ECoV, and therefore ECoV challenge studies are needed to evaluate efficacy of the vaccine in the future.
摘要
目前尚无针对马冠状病毒（ECoV）的疫苗。牛冠状病毒（BCoV）与ECoV存在抗原相关性；因此，BCoV疫苗有可能在马体内诱导产生抗ECoV的抗体。本研究调查了接种BCoV疫苗的马对ECoV的抗体反应。病毒中和试验表明，接种后14天，所有6匹受试马体内抗ECoV的抗体滴度均有所升高，尽管其抗ECoV的抗体滴度低于抗BCoV的抗体滴度。本研究表明，BCoV疫苗能在一定程度上为马提供抗ECoV的抗体。目前尚不清楚BCoV疫苗所提供的抗体对ECoV是否有效，因此未来需要进行ECoV攻毒试验来评估该疫苗的效力。
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