Commentary: The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's Disease.
作者信息
Squitti Rosanna, Salustri Carlo, Rongioletti Mauro, Siotto Mariacristina
机构信息
Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy.
Institute of Cognitive Sciences and Technologies (CNR), Rome, Italy.
出版信息
Front Neurol. 2017 Sep 25;8:503. doi: 10.3389/fneur.2017.00503. eCollection 2017.
Abstract
摘要
相似文献
1
Commentary: The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's Disease.评论：放弃阿尔茨海默病中铜离子治疗性螯合的理由。
Front Neurol. 2017 Sep 25;8:503. doi: 10.3389/fneur.2017.00503. eCollection 2017.
2
The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's Disease.放弃阿尔茨海默病中铜离子治疗性螯合的理由。
Front Neurosci. 2017 Jun 2;11:317. doi: 10.3389/fnins.2017.00317. eCollection 2017.
3
Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Abeta42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease.铝、铁、锌和铜会影响β淀粉样蛋白42（Aβ42）淀粉样纤维的体外形成，其影响方式可能会对阿尔茨海默病的金属螯合疗法产生影响。
J Alzheimers Dis. 2004 Jun;6(3):291-301. doi: 10.3233/jad-2004-6310.
4
Amyloid-beta: an antioxidant that becomes a pro-oxidant and critically contributes to Alzheimer's disease.
Free Radic Biol Med. 2001 Nov 1;31(9):1120-31. doi: 10.1016/s0891-5849(01)00688-8.
5
Current status of metals as therapeutic targets in Alzheimer's disease.金属作为阿尔茨海默病治疗靶点的现状
J Am Geriatr Soc. 2003 Aug;51(8):1143-8. doi: 10.1046/j.1532-5415.2003.51368.x.
6
Transition Metal Ion Interactions with Disordered Amyloid-β Peptides in the Pathogenesis of Alzheimer's Disease: Insights from Computational Chemistry Studies.过渡金属离子与阿尔茨海默病发病机制中无序淀粉样β肽的相互作用：计算化学研究的新见解。
J Chem Inf Model. 2019 May 28;59(5):1782-1805. doi: 10.1021/acs.jcim.8b00983. Epub 2019 Apr 15.
7
Alzheimer's amyloid-beta as a preventive antioxidant for brain lipoproteins.阿尔茨海默病的β-淀粉样蛋白作为脑脂蛋白的预防性抗氧化剂。
Cell Mol Neurobiol. 2001 Aug;21(4):299-315. doi: 10.1023/a:1012629603390.
8
Amyloid-beta metal interaction and metal chelation.淀粉样β蛋白与金属的相互作用及金属螯合作用。
Subcell Biochem. 2005;38:235-54. doi: 10.1007/0-387-23226-5_12.
9
Metal dyshomeostasis and oxidative stress in Alzheimer's disease.阿尔茨海默病中的金属动态平衡失调和氧化应激。
Neurochem Int. 2013 Apr;62(5):540-55. doi: 10.1016/j.neuint.2012.08.014. Epub 2012 Sep 8.
10
Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.螯合与嵌入：用于治疗阿尔茨海默病的化合物中的互补特性
J Struct Biol. 2000 Jun;130(2-3):209-16. doi: 10.1006/jsbi.2000.4285.
引用本文的文献
1
Copper homeostasis and cuproptosis in Alzheimer's disease (Review).阿尔茨海默病中的铜稳态与铜死亡（综述）
Int J Mol Med. 2025 Nov;56(5). doi: 10.3892/ijmm.2025.5613. Epub 2025 Aug 24.
2
Biometals in Alzheimer disease: emerging therapeutic and diagnostic potential of molybdenum and iodine.阿尔茨海默病中的金属生物：钼和碘的新兴治疗和诊断潜力。
J Transl Med. 2023 May 27;21(1):351. doi: 10.1186/s12967-023-04220-5.
3
Role of Metal Cations of Copper, Iron, and Aluminum and Multifunctional Ligands in Alzheimer's Disease: Experimental and Computational Insights.铜、铁和铝的金属阳离子及多功能配体在阿尔茨海默病中的作用：实验与计算见解
ACS Omega. 2023 Jan 25;8(5):4508-4526. doi: 10.1021/acsomega.2c06939. eCollection 2023 Feb 7.
4
Chelation Combination-A Strategy to Mitigate the Neurotoxicity of Manganese, Iron, and Copper?螯合联合策略——减轻锰、铁和铜的神经毒性？
Biomolecules. 2022 Nov 18;12(11):1713. doi: 10.3390/biom12111713.
5
Alzheimer's Drug PBT2 Interacts with the Amyloid β 1-42 Peptide Differently than Other 8-Hydroxyquinoline Chelating Drugs.阿尔茨海默病药物 PBT2 与淀粉样β 1-42 肽的相互作用不同于其他 8-羟基喹啉螯合药物。
Inorg Chem. 2022 Sep 19;61(37):14626-14640. doi: 10.1021/acs.inorgchem.2c01694. Epub 2022 Sep 8.
6
Copper Toxicity Links to Pathogenesis of Alzheimer's Disease and Therapeutics Approaches.铜毒性与阿尔茨海默病发病机制的关联及治疗方法。
Int J Mol Sci. 2020 Oct 16;21(20):7660. doi: 10.3390/ijms21207660.
7
A Preliminary Study of Cu Exposure Effects upon Alzheimer's Amyloid Pathology.铜暴露对阿尔茨海默病淀粉样蛋白病理的初步研究。
Biomolecules. 2020 Mar 6;10(3):408. doi: 10.3390/biom10030408.
8
Current Biomedical Use of Copper Chelation Therapy.当前铜螯合疗法在生物医学中的应用。
Int J Mol Sci. 2020 Feb 6;21(3):1069. doi: 10.3390/ijms21031069.
9
Copper signalling: causes and consequences.铜信号转导：病因与后果。
Cell Commun Signal. 2018 Oct 22;16(1):71. doi: 10.1186/s12964-018-0277-3.
10
Aroylhydrazones constitute a promising class of 'metal-protein attenuating compounds' for the treatment of Alzheimer's disease: a proof-of-concept based on the study of the interactions between zinc(II) and pyridine-2-carboxaldehyde isonicotinoyl hydrazone.酰腙类化合物是一类很有前途的“金属蛋白衰减化合物”，可用于治疗老年痴呆症：基于锌（II）与吡啶-2-甲醛异烟酰腙相互作用研究的概念验证。
J Biol Inorg Chem. 2018 Dec;23(8):1227-1241. doi: 10.1007/s00775-018-1606-0. Epub 2018 Aug 25.
本文引用的文献
1
Characterization of plasma metal profiles in Alzheimer's disease using multivariate statistical analysis.使用多变量统计分析对阿尔茨海默病患者的血浆金属谱进行特征分析。
PLoS One. 2017 Jul 18;12(7):e0178271. doi: 10.1371/journal.pone.0178271. eCollection 2017.
2
Patients with Increased Non-Ceruloplasmin Copper Appear a Distinct Sub-Group of Alzheimer's Disease: A Neuroimaging Study.非铜蓝蛋白结合铜升高的患者似乎是阿尔茨海默病的一个独特亚组：一项神经影像学研究。
Curr Alzheimer Res. 2017;14(12):1318-1326. doi: 10.2174/1567205014666170623125156.
3
Multifactorial Analysis of a Biomarker Pool for Alzheimer Disease Risk in a North Indian Population.印度北部人群中阿尔茨海默病风险生物标志物池的多因素分析
Dement Geriatr Cogn Disord. 2017;44(1-2):25-34. doi: 10.1159/000477206. Epub 2017 Jun 21.
4
The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's Disease.放弃阿尔茨海默病中铜离子治疗性螯合的理由。
Front Neurosci. 2017 Jun 2;11:317. doi: 10.3389/fnins.2017.00317. eCollection 2017.
5
Oxidative Stress Markers and Metal Ions are Correlated With Cognitive Function in Alzheimer's Disease.氧化应激标志物和金属离子与阿尔茨海默病的认知功能相关。
Am J Alzheimers Dis Other Demen. 2017 Sep;32(6):353-359. doi: 10.1177/1533317517709549. Epub 2017 May 29.
6
The Relationship Between Copper, Iron, and Selenium Levels and Alzheimer Disease.铜、铁、硒水平与老年痴呆症的关系。
Biol Trace Elem Res. 2018 Feb;181(2):185-191. doi: 10.1007/s12011-017-1042-y. Epub 2017 May 13.
7
Modeling of the Pathogenic Effect of Copper Transporter Mutations That Cause Menkes and Wilson Diseases, Motor Neuropathy, and Susceptibility to Alzheimer's Disease.导致门克斯病和威尔逊病、运动神经病以及阿尔茨海默病易感性的铜转运蛋白突变的致病效应建模
J Biol Chem. 2017 Mar 10;292(10):4113-4122. doi: 10.1074/jbc.M116.756163. Epub 2017 Jan 24.
8
Measurements of serum non-ceruloplasmin copper by a direct fluorescent method specific to Cu(II).采用针对Cu(II)的直接荧光法测定血清非铜蓝蛋白铜。
Clin Chem Lab Med. 2017 Aug 28;55(9):1360-1367. doi: 10.1515/cclm-2016-0843.
9
Non-ceruloplasmin bound copper and ATP7B gene variants in Alzheimer's disease.阿尔茨海默病中与铜蓝蛋白无关的铜及ATP7B基因变体
Metallomics. 2016 Sep 1;8(9):863-73. doi: 10.1039/c6mt00101g. Epub 2016 Aug 8.
10
Non-Ceruloplasmin Copper Distinguishes A Distinct Subtype of Alzheimer's Disease: A Study of EEG-Derived Brain Activity.非铜蓝蛋白铜可区分阿尔茨海默病的一种独特亚型：一项基于脑电图衍生脑活动的研究
Curr Alzheimer Res. 2016;13(12):1374-1384. doi: 10.2174/1567205013666160603001131.
Zotero 插件