Grimová J, Lastovicka J, Frycová H, Krejcí J
Research Institute for Pharmacy and Biochemistry, Prague, Czechoslovakia.
Agents Actions. 1988 Apr;23(3-4):373-5. doi: 10.1007/BF02142591.
The new antirheumatic drugs Benzofenac and Flobufen were assessed for their possible influence on various immunological parameters. They were shown to enhance passive cutaneous anaphylaxis (PCA) to ovalbumin in rats and to suppress the numbers of helper and suppressor T-lymphocytes in mice. The effect of Benzofenac in the latter system was found to be more pronounced. The drugs had no effects in any of the other test systems, including the development of delayed hypersensitivity, mitogen-induced lymphocyte proliferation in vitro and the production of antisera (as tested by PCA).
对新型抗风湿药物苯酰芬酸和氟苯布洛芬就其对各种免疫学参数可能产生的影响进行了评估。结果表明，它们可增强大鼠对卵清蛋白的被动皮肤过敏反应（PCA），并抑制小鼠体内辅助性和抑制性T淋巴细胞的数量。发现苯酰芬酸在后者系统中的作用更为明显。这些药物在任何其他测试系统中均无作用，包括迟发型超敏反应的发展、体外有丝分裂原诱导的淋巴细胞增殖以及抗血清的产生（通过PCA测试）。
