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新型2-氰基色酮的N-甲基-1,2,3-三唑衍生物的合成与药理学研究

Synthesis and pharmacological study of new N-methyl 1,2,3-triazole derivatives of 2-cyano chromones.

作者信息

Mouysset G, Payard M, Couquelet J, Bastide P, Stenger A, Delhon A, Tisne-Versailles J

机构信息

Département de Chimie, UFR de Pharmacie, Toulouse, France.

出版信息

Farmaco. 1990 Jul;45(7-8):847-57.

PMID:2177990
Abstract

The reaction of various 2-cyano chromones with diazomethane generated a series of 21 N-methyl triazoles, with a benzopyrone moiety and divided into three isomeric groups. The anti-inflammatory, psychotropic and anti-allergic effects of these new compounds were evaluated. The results obtained did not confirm their expected potentialities.

摘要

各种2-氰基色酮与重氮甲烷反应生成了一系列21种含苯并吡喃酮部分且分为三个异构体组的N-甲基三唑。对这些新化合物的抗炎、精神安定和抗过敏作用进行了评估。所获得的结果并未证实它们预期的潜力。

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