Rackwitz L, Reichert J C, Pullig O, Nöth U
Klinik für Orthopädie und Unfallchirurgie, Evangelisches Waldkrankenhaus Spandau, Stadtrandstraße 555, 13589, Berlin, Deutschland.
Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB, Translationszentrum Regenerative Therapien für Krebs- und Muskuloskelettale Erkrankungen - Institutsteil Würzburg, Würzburg, Deutschland.
Orthopade. 2017 Nov;46(11):947-953. doi: 10.1007/s00132-017-3479-2.
Cell and growth factor based strategies bear great potential to support the healing processes in cartilage repair and the therapy of osteoarthritic joints.
The following review provides an overview of novel experimental strategies for the therapy of focal cartilage defects and osteoarthritis, with emphasis on cell and growth factor based approaches.
The authors summarize their own data regarding the intraarticular injection of stem cells to treat osteoarthritis of the knee and provide a synopsis of the available literature discussing the most significant publications.
The development of novel strategies for the treatment of focal and arthrotic cartilage lesions focuses on the application of growth factors, platelet rich plasma (PRP), bone marrow (BMSAC) or adipose derived (stromal vascular fraction - SVF) cell concentrates, and ex vivo expanded mesenchymal stem cells (MSC). First clinical data on the use of expanded MSCs show the potential of this innovative therapeutic strategy. These approaches, however, are governed by EU law and often require approval by regulatory bodies.
Currently, only a limited number of published, randomized, controlled trials available. Therefore, it is not possible to finally assess the efficacy of these strategies at this point in time.
基于细胞和生长因子的策略在支持软骨修复和骨关节炎关节治疗的愈合过程方面具有巨大潜力。
以下综述概述了治疗局灶性软骨缺损和骨关节炎的新型实验策略，重点是基于细胞和生长因子的方法。
作者总结了他们自己关于关节内注射干细胞治疗膝关节骨关节炎的数据，并对讨论最重要出版物的现有文献进行了综述。
治疗局灶性和关节软骨损伤的新策略的发展集中在生长因子、富血小板血浆（PRP）、骨髓（BMSAC）或脂肪来源（基质血管成分 - SVF）细胞浓缩物以及体外扩增的间充质干细胞（MSC）的应用上。关于使用扩增的间充质干细胞的首批临床数据显示了这种创新治疗策略的潜力。然而，这些方法受欧盟法律管辖，并且通常需要监管机构的批准。
目前，仅有数量有限的已发表的随机对照试验。因此，目前无法最终评估这些策略的疗效。
