Small J G, Klapper M H, Kellams J J, Miller M J, Milstein V, Sharpley P H, Small I F
Department of Psychiatry, Larue D. Carter Memorial Hospital, Indiana University School of Medicine, Indianapolis 46202.
Arch Gen Psychiatry. 1988 Aug;45(8):727-32. doi: 10.1001/archpsyc.1988.01800320037004.
Thirty-four hospitalized manic patients were randomized to treatment with either lithium carbonate or an average series of nine bilateral electroconvulsive treatments (ECTs), followed by maintenance with lithium carbonate. Weekly ratings of manic, depressive, and psychotic symptoms were obtained for eight weeks, and patients were followed up monthly for up to two years. Ratings by nonblind and blind observers indicated that the patients who underwent ECT improved more during the first eight weeks than did patients who were treated with lithium carbonate. This was especially true of patients with mixed symptoms of mania and depression and/or extreme manic behavior. Clinical ratings after eight weeks showed no significant differences between the lithium carbonate- and ECT-treated patients. Likewise, the two groups had comparable rates of relapse, recurrence, and rehospitalization during the follow-up period.
34名住院躁狂患者被随机分为两组，一组接受碳酸锂治疗，另一组接受平均9次的双侧电休克治疗（ECT），随后用碳酸锂维持治疗。在八周内每周对躁狂、抑郁和精神病症状进行评分，并对患者进行长达两年的每月随访。非盲和盲观察者的评分表明，接受ECT治疗的患者在前八周内比接受碳酸锂治疗的患者改善得更多。对于有躁狂和抑郁混合症状和/或极端躁狂行为的患者尤其如此。八周后的临床评分显示，碳酸锂治疗组和ECT治疗组之间没有显著差异。同样，在随访期间，两组的复发、再发和再住院率相当。
