Yang Zi-Ping, Bao Yi-Min
College of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhongguo Zhong Yao Za Zhi. 2017 Mar;42(5):870-874. doi: 10.19540/j.cnki.cjcmm.20170121.010.
Mitochondria is the key energy source of cells and plays an important role in energy synthesis and release, and maintenance of cellular functions. As the most important active ingredients in Chinese medicine pseudo-ginseng, Panax notoginseng saponins(PNS) have pharmacological effects on protecting against thrombosis, dilating blood vessels, lowering the blood pressure, anti-inflammation, and antioxidant, etc. Domestic and foreign studies have shown that PNS participates in regulating mitochondrial energy metabolism, oxidative stress, biosynthesis, apoptosis, mitophagy and the status of membrane channels. Therefore, the mitochondria is one of the important targets of PNS. In this paper, the regulation effects of P. notoginseng saponins on mitochondria were reviewed.
线粒体是细胞的关键能量来源，在能量合成与释放以及细胞功能维持方面发挥着重要作用。三七总皂苷（PNS）作为中药三七中最重要的活性成分，具有抗血栓形成、扩张血管、降低血压、抗炎和抗氧化等药理作用。国内外研究表明，PNS参与调节线粒体能量代谢、氧化应激、生物合成、细胞凋亡、线粒体自噬以及膜通道状态。因此，线粒体是PNS的重要作用靶点之一。本文综述了三七总皂苷对线粒体的调节作用。
