Yang Peng-fei, Song Xiu-yun, Chen Nai-hong
Yao Xue Xue Bao. 2016 Jul;51(7):1039-46.
Sanqi in Chinese herbal medicine is the root and rhizoma of Panax notoginseng (Burk.) F.H. Chen, which belongs to genus Panax in the Araliaceae family and is widely used as a tonic medicine in the traditional Chinese medicine. The main active constituents of sanqi are Panax notoginseng saponins, including ginsenoside Rg1, Rb1 and notoginsenoside R1. A wide variety of pharmaceutical applications of Panax notoginseng saponins have been reported in the regulation of blood circulation system, cardiovascular system and nervous system. Ischemic stroke, the most common form of stroke, leads to a high risk of morbidity and disability, which evolves serious medical, social and economic problems. Ischemia-reperfusion injury is the most important part in the progress of ischemic stroke. Abnormal energy metabolism, disturbance of the ion metabolism, free radical injury, inflammatory reactions all participate in the complex pathological mechanisms of ischemia- reperfusion injury. Over the past few decades, substantial studies demonstrated that Panax notoginseng saponins possessed a significant protective effect on ischemia-reperfusion injury. However, little is known about the underlying mechanisms of the protective effects. In order to develop a new medicine from Panax notoginseng, we provide a review of the major literatures on the pharmaceutical actions and molecular mechanisms of Panax notoginseng and Panax notoginseng saponins in the protection of ischemia-reperfusion injury.
中药三七为五加科人参属植物三七（Panax notoginseng (Burk.) F.H. Chen）的干燥根和根茎，是传统中药中广泛应用的滋补药材。三七的主要活性成分是三七皂苷，包括人参皂苷Rg1、Rb1和三七皂苷R1。三七皂苷在血液循环系统、心血管系统及神经系统调节方面具有广泛的药学应用报道。缺血性脑卒中是最常见的脑卒中类型，具有较高的致残率和致死率，引发了严重的医疗、社会及经济问题。缺血再灌注损伤是缺血性脑卒中发展过程中最重要的环节。能量代谢异常、离子代谢紊乱、自由基损伤及炎症反应均参与了缺血再灌注损伤的复杂病理过程。过去几十年，大量研究表明三七皂苷对缺血再灌注损伤具有显著保护作用。然而，其保护作用的潜在机制尚不清楚。为了开发基于三七的新药，我们对三七及三七皂苷在保护缺血再灌注损伤方面的药理作用及分子机制的主要文献进行综述。
