Balázs M, Schwarzberg H, Telegdy G
Department of Pathophysiology, University Medical School, Szeged, Hungary.
Eur J Pharmacol. 1988 Apr 27;149(1-2):141-4. doi: 10.1016/0014-2999(88)90052-0.
The effects of somatostatin on lateral hypothalamic self-stimulation were investigated in rats pretreated with haloperidol, bicuculline, phenoxybenzamine or propranolol. Somatostatin decreased the rate of self-stimulation. Halperidol, bicuculline and phenoxybenzamine potentiated the somatostatin-induced depression of self-stimulation behaviour. Propranolol had no effect. It is suggested that dopaminergic, GABAergic and noradrenergic systems are involved in the somatostatin-induced depression of self-stimulation.
在分别用氟哌啶醇、荷包牡丹碱、酚苄明或普萘洛尔预处理的大鼠中，研究了生长抑素对下丘脑外侧自我刺激的影响。生长抑素降低了自我刺激的速率。氟哌啶醇、荷包牡丹碱和酚苄明增强了生长抑素诱导的自我刺激行为抑制。普萘洛尔没有作用。提示多巴胺能、γ-氨基丁酸能和去甲肾上腺素能系统参与了生长抑素诱导的自我刺激抑制。
