Balázs M, Telegdy G
Department of Pathophysiology, University Medical School, Szeged, Hungary.
Pharmacol Biochem Behav. 1988 Nov;31(3):515-8. doi: 10.1016/0091-3057(88)90224-9.
The actions of blockers of dopaminergic receptors (haloperidol), alpha-receptors (phenoxybenzamine), beta-receptors (propranolol) and muscarinic cholinergic receptor (atropine) on the ACTH-induced delay of the extinction of active avoidance behavior were studied in rats. In the doses used, none of the receptor blockers modified the extinction of active avoidance behavior. ACTH delayed the extinction. However, the dopamine receptor blocker (haloperidol) and the muscarinic cholinergic receptor blocker (atropine) did prevent the action of ACTH in delaying the extinction of active avoidance behavior, whereas the alpha-(phenoxybenzamine) and beta- (propranolol) receptor blockers were ineffective. The results suggest that mainly dopaminergic and cholinergic mediations are involved in the delaying action of ACTH on the extinction of active avoidance behavior.
在大鼠中研究了多巴胺能受体阻滞剂（氟哌啶醇）、α受体阻滞剂（酚苄明）、β受体阻滞剂（普萘洛尔）和毒蕈碱胆碱能受体阻滞剂（阿托品）对促肾上腺皮质激素（ACTH）诱导的主动回避行为消退延迟的作用。在所使用的剂量下，没有一种受体阻滞剂改变主动回避行为的消退。ACTH延迟了消退。然而，多巴胺受体阻滞剂（氟哌啶醇）和毒蕈碱胆碱能受体阻滞剂（阿托品）确实阻止了ACTH延迟主动回避行为消退的作用，而α受体阻滞剂（酚苄明）和β受体阻滞剂（普萘洛尔）则无效。结果表明，ACTH对主动回避行为消退的延迟作用主要涉及多巴胺能和胆碱能介导。
