十八碳-9,11-二烯酸在宫颈肿瘤中的诊断意义

Diagnostic significance of octadeca-9,11-dienoic acid in cervical neoplasia.

作者信息

Green A J, Starkey B J, Halloran S P, McKee G, Sutton C J, Manners B T, Walker A W

机构信息

Department of Clinical Biochemistry, St Luke's Hospital, Guildford, Surrey.

出版信息

Lancet. 1988 Aug 6;2(8606):309-11. doi: 10.1016/s0140-6736(88)92358-6.

DOI:10.1016/s0140-6736(88)92358-6

PMID:2899722

Abstract

The percentage molar ratio (%MR) of the 9,11 and 9,12 isomers of octadecadienoic acid was determined in cervical exfoliated cells from 148 subjects, of whom 27 had cytologically proven intraepithelial neoplasia and in cervical biopsy specimens from 43 subjects, of whom 24 had histologically diagnosed cervical intraepithelial neoplasia. The %MR in both cervical biopsy specimens and exfoliated cells did not significantly differ in subjects with or without cervical intraepithelial neoplasia. The measurement of the %MR of 9,11:9,12 octadecadienoic acid has no role in the detection of cervical intraepithelial neoplasia.

摘要

在148名受试者的宫颈脱落细胞中测定了十八碳二烯酸9,11和9,12异构体的摩尔百分比（%MR），其中27例经细胞学证实为上皮内瘤变；在43名受试者的宫颈活检标本中也进行了测定，其中24例经组织学诊断为宫颈上皮内瘤变。在有或没有宫颈上皮内瘤变的受试者中，宫颈活检标本和脱落细胞中的%MR没有显著差异。9,11:9,12十八碳二烯酸%MR的测定在宫颈上皮内瘤变的检测中没有作用。