通过评估脱落细胞中自由基反应产物（9,11-十八碳二烯酸）来识别宫颈肿瘤。

Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in exfoliated cells.

作者信息

Tay S K, Singer A, Griffin J F, Wickens D G, Dormandy T L

出版信息

Clin Chim Acta. 1987 Mar 16;163(2):149-52. doi: 10.1016/0009-8981(87)90017-9.

Abstract

The molar ratio between a diene-conjugated linoleic-acid isomer (18:2(9,11)) and the parent linoleic acid (18:2(9,12)), both esterified as phospholipids, was significantly different in exfoliated cells from normal cervices and from cervices with colposcopic and cytological evidence of precancer. The measurement may provide a simple and perhaps improved alternative to cytological screening.

摘要

作为磷脂被酯化的共轭亚油酸二烯异构体（18:2(9,11)）与母体亚油酸（18:2(9,12)）之间的摩尔比，在来自正常宫颈以及有阴道镜和细胞学证据显示存在癌前病变的宫颈的脱落细胞中存在显著差异。该测量方法可能为细胞学筛查提供一种简单且或许有所改进的替代方法。