Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in biopsy material.
作者信息
Griffin J F, Wickens D G, Tay S K, Singer A, Dormandy T L
出版信息
Clin Chim Acta. 1987 Mar 16;163(2):143-8. doi: 10.1016/0009-8981(87)90016-7.
PMID:3568417
Abstract
Linoleic acid (18:2(9,12)) and its diene-conjugated isomer (18:2(9,11)) were measured in 65 cervical biopsy samples. Both the 18:2(9,11) concentration and the 18:2(9,11)/18:2(9,12) molar ratio showed highly significant differences between the normal and precancerous groups. Both showed a further significant increase in 4 invasive carcinomas. The findings in histologically normal areas from organs with precancer correlated significantly with the results in the precancerous lesions.
摘要
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