Beynon H L, Garbett N D, Barnes P J
Department of Thoracic Medicine, Brompton Hospital, London.
Lancet. 1988 Aug 13;2(8607):370-2. doi: 10.1016/s0140-6736(88)92837-1.
Three patients with severe premenstrual exacerbations of asthma are reported. None had responded to conventional treatment, including high-dose corticosteroids. In all cases there was a striking fall premenstrually in peak flow rate. The addition of intramuscular progesterone (100 mg daily in two cases and 600 mg twice a week in one) to the regimen eliminated the premenstrual dips in peak flow, and daily doses of prednisolone were reduced in the three patients.
报告了3例哮喘在月经前严重加重的患者。这些患者均对包括大剂量皮质类固醇在内的传统治疗无反应。所有病例的呼气峰值流速在月经前均显著下降。在治疗方案中添加肌肉注射黄体酮（2例每日100mg，1例每周两次600mg）消除了月经前呼气峰值流速的下降，且3例患者的泼尼松龙每日剂量均有所减少。
