Schnipper L E, Lewin A A, Crumpacker C S
Mutat Res. 1983 Feb;116(2):65-72. doi: 10.1016/0165-1218(83)90097-6.
Enhanced survival of UV-irradiated HSV-1 is demonstrated in monkey cells exposed to inhibitors of viral DNA synthesis. Phosphonoacetic acid (PAA), adenine arabinoside (ara-A), and cytosine arabinoside (ara-C) pretreatment of infected cells is associated with concentration-dependent reactivation of UV-HSV-1. At concentrations that result in enhanced virus survival, inhibition of cell DNA synthesis is observed by either ara-A or ara-C, but not by PAA. Pretreatment of uninfected cells with acycloguanosine (ACG) is not associated with reactivation of irradiated HSV-1, and this is probably due to insufficient generation of ACG-triphosphate, the active inhibitor of viral and cell DNA synthesis.
在暴露于病毒DNA合成抑制剂的猴细胞中，紫外线照射的单纯疱疹病毒1型（HSV-1）的存活率有所提高。用膦甲酸（PAA）、阿糖腺苷（ara-A）和阿糖胞苷（ara-C）对感染细胞进行预处理，与紫外线照射的HSV-1浓度依赖性再激活有关。在导致病毒存活率提高的浓度下，阿糖腺苷或阿糖胞苷可观察到细胞DNA合成受到抑制，但膦甲酸不会。用阿昔洛韦（ACG）对未感染细胞进行预处理与照射后的HSV-1再激活无关，这可能是由于ACG三磷酸（病毒和细胞DNA合成的活性抑制剂）生成不足所致。
