眼部单纯疱疹病毒感染：原发性疾病中对阿昔洛韦的敏感性降低。
Ocular herpes simplex virus infections: reduced sensitivity to acyclovir in primary disease.
作者信息
Charles S J, Gray J J
机构信息
Addenbrooke's Hospital, Department of Ophthalmology, Cambridge.
出版信息
Br J Ophthalmol. 1990 May;74(5):286-8. doi: 10.1136/bjo.74.5.286.
Abstract
Forty isolates of herpes simplex virus (HSV) obtained from ocular herpetic infections were assayed for their sensitivity to five antiviral agents. There were wide ranges of sensitivity to foscarnet, idoxuridine, and vidarabine, but the majority were sensitive to acyclovir and ganciclovir. Reduced sensitivity to acyclovir was seen in four isolates, all of which were from primary infections acquired in the community and without a previous history of treatment with antiviral drugs.
摘要
对从眼部疱疹感染中分离出的40株单纯疱疹病毒（HSV）进行了5种抗病毒药物的敏感性检测。这些病毒对膦甲酸、碘苷和阿糖腺苷的敏感性差异很大，但大多数对阿昔洛韦和更昔洛韦敏感。4株病毒对阿昔洛韦敏感性降低，所有这些病毒均来自社区获得的原发性感染，且既往无抗病毒药物治疗史。
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